PGT – For Chromosomal Diseases and Disorders

PGT (Preimplantation Genetic Diagnosis) is a procedure where embryos obtained under laboratory conditions are subjected to genetic testing before being transferred to the mother's uterus.

A human embryo has a total of 46 chromosomes (23 pairs), half from the mother and half from the father. Due to factors such as the age of the prospective mother, the presence of structural chromosomal abnormalities (like translocations) in one or both parents, or other biological and environmental reasons, the risk of numerical or structural abnormalities in embryos may increase.

Most chromosomal abnormalities are incompatible with life, meaning the embryo may stop developing either in the embryonic stage or before implantation in the uterus. A portion of those that do implant (such as trisomy 13, 16, 18, 21, 22; monosomy X) often result in miscarriage, while a small percentage (microdeletion syndromes, monosomy X [Turner syndrome], and trisomy 21 [Down syndrome]) can lead to the birth of children with various degrees of intellectual disabilities.

Through the PGT test, normal embryos can be identified in these high-risk groups, reducing the risk of miscarriage and increasing the success rate of IVF treatments.

This test, increasingly common among IVF patients worldwide and in our country, is especially recommended for couples with a high risk of producing chromosomally abnormal embryos.

For example, PGT is recommended in cases of:

• Advanced maternal age,
• Recurrent miscarriages,
• Repeated failed IVF attempts,
• Genetic disease carriers (such as translocations, inversions),
• Severe male infertility,
• Couples with a history of chromosomally abnormal pregnancies.

The PGT test is performed on cells taken via biopsy on the 3rd or 5th day of embryonic development. With advancements in freezing techniques and culture methods, the test is now largely performed on embryos that have reached the blastocyst stage (day 5 or day 6), followed by vitrification (freezing) techniques. Based on the PGT results, transfer occurs in the next treatment cycle.

When performed under appropriate conditions by an experienced embryologist, the freezing process does not decrease the embryo's development or pregnancy potential. In fact, many scientific studies have shown that success rates are higher when embryos are transferred after freezing and resting the uterus, compared to fresh transfers.

Due to legal regulations, we cannot publish PGT test price information on our website. For current price information, please fill out our contact form or reach us at 444 39 49.

Fill out our contact form for pricing information.