Smart PGT-A Plus

Introducing Smart PGT-A Plus, a revolutionary genetic testing method that enhances the chances of success in IVF by allowing for a more detailed and precise chromosomal analysis of embryos. As with all fields, we are delighted to closely follow and rapidly introduce new technologies in genetic science to benefit our patients. Find answers to many questions such as 'What is Smart PGT-A Plus, and who is it suitable for?' and 'Does Smart PGT-A Plus improve IVF success?' in our article.

Smart PGT-A Plus is a novel genetic test that performs a more detailed and highly accurate chromosomal analysis of embryos, a breakthrough method applied in only a few countries.

Developed as a confirmatory and supportive additional method alongside the traditional PGT-A method, where cells are biopsied from embryos to evaluate their chromosomal count, structural features, and overall genetic health. After the analysis, the most suitable embryos for transfer are identified, increasing the success rates per transfer.

Compared to the traditional PGT-A approach, Smart PGT-A Plus offers higher precision, detecting micro-level changes in the embryo's chromosomal set. Moreover, many abnormalities that cannot be detected by the traditional method become visible with the use of this new technology.

Known as 'Targeted Next-Generation Sequencing,' the Smart PGT-A Plus application allows technology to advance a step further, making it easier to detect certain specific conditions that were previously in the shadows. By facilitating the selection of healthy embryos, Smart PGT-A Plus enhances the chances of success in IVF.

• Mothers aged 35 and above
• Those with a history of recurrent pregnancy loss
• Individuals with a history of repeated implantation failure
• Those with a history of chromosomal abnormalities in children or pregnancies
• Cases of severe male factor infertility or a high rate of diploidy in sperm
• A history of triploid pregnancy
• A history of molar pregnancy
• Patients with high-quality embryos derived from oocytes with observed abnormal fertilization (1PN, 3PN) to enhance pregnancy success

PGT-A Plus is a genetic test developed to enhance success in IVF treatments. This method enables a more detailed and precise genetic analysis by targeting specific markers in the chromosomes, assisting in the selection of healthy embryos. Here's how Smart PGT-A Plus plays a role in improving IVF success:

• High Accuracy and Reliability: By adding an extra test to the classical PGT-A, it is possible to verify the results obtained in classical PGT-A applications. Moreover, this additional evaluation is performed in the same session without the need to re-biopsy embryos. It offers more reliable results by applying two independent analysis techniques to detect abnormalities, significantly reducing the risk of human error in diagnosis.
• Reduces the Risk of Miscarriage and Molar Pregnancy: It detects chromosomal count abnormalities that cannot be identified by the traditional technique, increasing the chances of a healthy pregnancy and minimizing the risk of miscarriage and molar pregnancy (gestational trophoblastic disease). This positively affects the success rates of treatment.
• Increases the Number of Transferable Embryos: In practical terms, embryos showing abnormal fertilization are excluded from transfer. However, it is known that some of these embryos can transform into quality and healthy embryos by using genetic repair mechanisms. This new technology prevents the exclusion of these healthy embryos by detecting changes in chromosomal set quantity, offering a chance for the transfer of embryos that may appear to have abnormal fertilization. This is an additional opportunity for patients who obtain very few embryos.
• Enhanced Quality Assurance and Reduced Risk of Misdiagnosis: It reduces the risk of misdiagnosis through advanced quality control methods. During embryo biopsy, it is not possible to detect and remove DNA particles from the mother that are processed during the procedure. With the Smart PGT-A Plus technology, these technical details can be identified, providing a high level of accurate reporting by detecting situations that could lead to incorrect reporting using the traditional method.

Smart PGT-A Plus, with its advanced technology in genetic analysis and the ability for detailed examination, may help achieve more effective results in IVF treatments. However, every patient has different clinical features, so it is important to undergo a detailed evaluation with your specialist before starting treatment.