PRP Method

It has been reported that PRP application can be used in two different ways in the fields on IVF: rejuvenation of ovarian tissue and the thickening of the uterine membrane (endometrium).

PRP application; the platelet rich plasma prepared by the individuals own blood is delivered into the ovary or uterus. If PRP is to be administered into the uterus, the patient is not anesthetized as the treatment is painless. If applied into the ovary the treatment is carried out under anaesthesia and again the patient does not feel any pain.

The first study on human rejuvenation with PRP was presented in 2016 in the Congress of the European Society of Human Reproductive Medicine and Embryology (ESHRE). In the study, it was reported that follicle development and mature egg production were achieved in 8 menopausal women (mean 1.5 mature egg cells) and obtained embryos were frozen.

Afterwards, there are studies that carried out similar practices, and there are several studies that indicate that the PRP application can be used to solve the mentioned problems, but there are controversial points in terms of content. Although the studies have resulted in pregnancy, there is not yet enough data to suggest that the PRP method provides a statistical success in these cases. Similarly, some improvements have been observed in the applications of PRP in the uterus of patients with uterine membrane problems, there is no satisfactory evidence in the literature that PRP is statistically successful.

Patients who have undergone many failed trials or diagnosed with early menopause and have a limited number of egg development have high hopes for PRP. However, as mentioned above it should be considered that there is not enough scientific data on this subject. It should be kept in mind at this stage that even if before the menopause, every woman who is able to respond to the conventional IVF treatments can have a certain chance of pregnancy. New medical studies need to be done in order to find out that applications such as PRP are clinically safe and increase success, and people in similar cases should be compared with and without PRP treatment to have accurate statistics.

With the current developments, there are 3 points that should be considered before deciding if PRP increases success in IVF treatments;

1) How secure is the technique? The PRP method has not yet proven success in the field of reproductive medicine, and we do not have enough data on the possible negative effects and safe use of the tissues and organs in which it is applied. Considering the application of ovarian rejuvenation, the PRP solution is considered to be an interventional procedure because it is given to the ovary with the help of a needle passing through the vagina as in the same egg collection (OPU). Like any interventional procedure, this procedure should be followed in order to see if there are any significant problems in terms of the health of the patien both during and after the procedure.

2) How is the expected ovarian rejuvenation or uterine thickening after PRP administration? Although a plasma rich in growth hormones is used, it is largely unknown as to whether PRP may play a role in the rejuvenation of the ovary as we do not know the factor or factors that may have a role on ovary rejuvenation.

3) How successful is the technique? Hormonal parameters that are taken from an extremely limited study group and eggs obtained after egg development are far from showing that the technique is widely applicable to the general patient group. In the case of thickening of the uterine membrane, the available data is not of a quality to show that the technique is a success. The answer to this question is therefore unclear currently.

According to the law, we cannot share the price information of the PRP application on our website. You can fill in our contact form or contact us on 444 39 49 to get detailed information about PRP supported IVF treatment