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In light of new information, it has been proven that the use of EmbryoGlue increases success rates in IVF treatments. This method began being implemented at Bahçeci simultaneously with the recommendation from the world’s leading reproductive health organization, ESHRE. In a study published by ESHRE in October 2023, involving 6,704 women, it was shown that the application of EmbryoGlue during both day 3 (cleavage stage) and day 5 (blastocyst) embryo transfers significantly increased live birth rates. It has been proven that it enhances pregnancy by preventing issues with the embryo adhering to the uterus after the transfer procedure. You can find answers to questions like "What is EmbryoGlue?" and "Who is EmbryoGlue suitable for?" in our article.
EmbryoGlue is a special transfer medium that contains hyaluronic acid. Hyaluronic acid is a molecule naturally produced by our bodies and is found abundantly in our tissues. It is a sticky substance that gives our tissues elasticity and firmness, holding them together. It is frequently used for cosmetic purposes, especially for skin health and beauty. In IVF treatments, it plays a bonding and adhesive role that helps the embryo adhere to the uterine wall after the transfer.
Studies with EmbryoGlue have shown that clinical pregnancy rates significantly increase in frozen-thawed embryo transfers applied to patients with repeated implantation failures. Additionally, it can double the pregnancy rate in patient groups with poor-quality embryos. Therefore, it has an effect in increasing IVF success in cases of advanced maternal age and recurrent pregnancy losses.
EmbryoGlue is a special transfer medium used during the embryo transfer process. The selected embryo is transferred to the uterus along with this medium. It is known that the use of this fluid increases the chances of the embryo adhering to the uterine wall and the pregnancy rate. It began to be applied at Bahçeci simultaneously with its recommendation by the European Society of Human Reproduction and Embryology (ESHRE). The decision to use EmbryoGlue should be made at least one day before the transfer day, and laboratory preparations should be made accordingly. The selected embryos are combined with EmbryoGlue shortly before the transfer procedure. The transfer medium and the embryo inside it are loaded into the catheter together at the time of transfer and transferred to the uterus. The high viscosity of the fluid allows the embryo to have more contact with the inner wall of the uterus, increasing the chances of implantation.
Although we transfer the best embryo into a uterus ready for pregnancy during embryo transfers, pregnancy does not always occur. Many biological mechanisms, some of which are still unknown, play a role in the successful implantation of a quality embryo into the uterine wall. However, it is not always possible to identify the missing piece of the puzzle in treatments that do not result in pregnancy. The most critical condition for pregnancy is the embryo making contact with the lining of the uterus. The cells of the embryo encounter the cells of the prospective mother for the first time in this way and begin the process of implantation. By adding some sticky, natural substances to the transfer mediums, the contact time between the embryo and the uterine wall cells increases. Hyaluronic acid is a naturally occurring molecule found abundantly in the female reproductive system. There is an increase in its amount in the uterus during the embryo implantation phase. It is one of the best-known molecules responsible for adhesion between cells in the body. The use of EmbryoGlue supports the embryo's adhesion to the uterus and increases the chances of pregnancy.
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